Vitamin D in chronic kidney disease
Vitamin D is an important hormone in the regulation of mineral metabolism and in bone remodeling and mineralization. Existence of vitamin D receptors (VDRs) in many cells is evidence that vitamin D is important in many other physiological processes as well. Vitamin D deficiency is present in a large number of healthy individuals, especially in patients with chronic kidney disease (CKD). Unfortunately, there are no clear recommendations on how and when to compensate for vitamin D deficiency in CKD patients. The effect of native vitamin D (ergocalciferol or cholecalciferol) on mineral metabolism is much less pronounced than the effect of calcitriol or vitamin D analogues. Nevertheless, ergocalciferol and cholecalciferol may, due to their effect on VDR in many cells, have beneficial impact on the local autocrine and paracrine effect of calcitriol.
Key words:
chronic kidney disease; vitamin D
OGLASI
