MEDIX, God. 28 Br. 152  •  Pregledni članak  •  Klinička imunologija HR ENG

Vitamin D u kroničnoj bubrežnoj bolestiVitamin D in chronic kidney disease

Draško Pavlović, Dajana Katičić, Boris Kudumija

Vitamin D je važan hormon u regulaciji mineralnog metabolizma i u pregradnji i mineralizaciji kostiju. Postojanje receptora za vitamin D (VDR) u mnogim stanicama dokaz je da vitamin D ima značenje i u mnogim drugim fiziološkim procesima. Manjak vitamina D prisutan je u velikome broju zdravih osoba, a posebno u bolesnika s kroničnom bubrežnom bolešću. Nažalost, ne postoje jasne preporuke kako i kada nadoknaditi vitamin D u KBB-u. Učinak nativnog vitamina D (ergokalciferola ili kolekalciferola) na mineralni metabolizam mnogo je slabije izražen nego učinak kalcitriola ili analoga vitamina D. Ipak ergokalciferol i kolekalciferol mogu svojim učinkom na VDR u mnogim stanicama imati povoljan učinaka na lokalno autokrino i parakrino djelovanje kalcitriola.

Ključne riječi:
kronična bubrežna bolest; vitamin D

Članak u cijelosti pročitajte u tiskanom izdanju MEDIX, God. 28 Br. 152

Vitamin D is an important hormone in the regulation of mineral metabolism and in bone remodeling and mineralization. Existence of vitamin D receptors (VDRs) in many cells is evidence that vitamin D is important in many other physiological processes as well. Vitamin D deficiency is present in a large number of healthy individuals, especially in patients with chronic kidney disease (CKD). Unfortunately, there are no clear recommendations on how and when to compensate for vitamin D deficiency in CKD patients. The effect of native vitamin D (ergocalciferol or cholecalciferol) on mineral metabolism is much less pronounced than the effect of calcitriol or vitamin D analogues. Nevertheless, ergocalciferol and cholecalciferol may, due to their effect on VDR in many cells, have beneficial impact on the local autocrine and paracrine effect of calcitriol.

Key words:
chronic kidney disease; vitamin D