New paradigms of obesity, metabolic syndrome and NAFLD pathogenesis – impact on diet therapy
Nonalcoholic fatty liver disease (NAFLD) is one of the most common forms of liver disease in the developed and some developing countries. Despite various health campaigns and interventions, the epidemic of metabolic syndrome and NAFLD is still on the rise, even in children and adolescents. To explain the metabolic consequences of obesity more closely, in recent years the carbohydrate-insulin model of obesity pathogenesis has emerged as a supplement to the classical model of energy balance. This new model of obesity pathogenesis could explain the metabolic mechanisms of the negative impact of high-glycemic load ultra-processed food and the positive impact of the Mediterranean diet on cardiometabolic health. Further research in this direction could be the basis for revised dietary therapy recommendations for treating NAFLD and other metabolic diseases.
Key words:
carbohydrate-insulin model; metabolic syndrome; non-alcoholic fatty liver disease; obesity
