Malignant lymphomas in children

Abstract:

In the last ten years, great progress has been made in diagnosis and treatment of children with malignant lymphomas. Due to new treatment methods (new combinations of cytostatic agents, irradiation, surgery, monoclonal antibodies and bone marrow transplantation), long-term remission and cure are achieved in 75-98% of the cases. The aim of diagnostic evaluation is to determine the type of lymphoma, extent of the disease, prognostic factors and possible comorbidity. The main goal of treatment is remission and cure, with as little early and late complications as possible. Patients with aggressive and resistant forms of non-Hodgkin’s lymphoma (NHL) are treated by intensive protocols, including radiotherapy, peripheral stem cell transplantation and monoclonal antibodies. The use of monoclonal antibodies in the initial treatment of patients with B-NHL is still investigated, as well as their use in patients with B-NHL types with poor prognosis. 

Key words:
child; lymphoma; treatment