Liposomes in corrective dermatology

Abstract:

Liposomes are biocompatible phospholipid nanovesicles used for improved dermal delivery of active substances. The advantages of dermal application of liposomes include: increased skin hydration, enhanced delivery of active substances in the lower layers of the epidermis, encapsulation of of hydrophilic, lipophilic and amphipathic substances, biodegradability, biocompatibility, non-toxicity, nonimmunogenicity and controlled/sustained release of encapsulated substances. The physicochemical properties of liposomes, such as size, surface charge, membrane elasticity and ability of integrating active substances, significantly contribute to the efficacy of delivering encapsulated content into the skin. Different types of phospholipid vesicles have been developed and investigated including conventional and deformable liposomes, ethosomes and propylene glycol liposomes. Numerous clinical studies prove the superiority of liposomes in comparison to conventional formulations. 

Key words:
liposomes; nanocosmeceuticals; penetration; skin; topical delivery