Multiple sclerosis – symptoms and signs

Abstract:

Multiple sclerosis is the most common demyelinating disease of the central nervous system (CNS), characterized by multi-centric inflammatory destruction of myelin and axonal damage. Initial phase of the disease is dominated by inflammatory component and neurological damage being reversible, but over time a neurodegenerative phase of the disease appears along with irreversible deficit. This is why it is important to diagnose the disease as soon as possible and start treatment early. The clinical picture of the disease varies. In the diagnosis of multiple sclerosis, clinical (signs and symptoms of disease and neurologic disorders) and para-clinical parameters are important, the most important being magnetic resonance imaging (MRI) of the brain and spinal cord, evoked potentials (EP) and cerebrospinal fluid analysis. 

Key words:
clinical picture; multiple sclerosis