MEDIX, God. 20 Br. 111  •  Pregledni članak  •  Neurologija HR ENG

Klinička slika multiple sklerozeMultiple sclerosis – symptoms and signs

Marija Bošnjak Pašić

Multipla skleroza je najčešća demijelinizacijska bolest središnjega živčanog sustava (SŽS) obilježena multicentričnom upalnom destrukcijom mijelina i oštećenjem aksona. U početku bolesti dominira upalna komponenta, a neurološko oštećenje je reverzibilno, no protokom vremena nastupa neurodegenerativna faza bolesti s ireverzibilnim deficitom. Upravo je zato važno što prije bolest dijagnosticirati i rano liječiti. Klinička je slika bolesti raznolika. U dijagnostici multiple skleroze važni su klinički (znakovi i simptomi bolesti te neurološki deficiti) i paraklinički parametri od kojih su najvažniji nalazi magnetske rezonancije (MR) mozga i kralježnične moždine, evocirani potencijali (EP) i analiza likvora. 

Ključne riječi:
klinička slika; multipla skleroza

Članak u cijelosti pročitajte u tiskanom izdanju MEDIX, God. 20 Br. 111

Multiple sclerosis is the most common demyelinating disease of the central nervous system (CNS), characterized by multi-centric inflammatory destruction of myelin and axonal damage. Initial phase of the disease is dominated by inflammatory component and neurological damage being reversible, but over time a neurodegenerative phase of the disease appears along with irreversible deficit. This is why it is important to diagnose the disease as soon as possible and start treatment early. The clinical picture of the disease varies. In the diagnosis of multiple sclerosis, clinical (signs and symptoms of disease and neurologic disorders) and para-clinical parameters are important, the most important being magnetic resonance imaging (MRI) of the brain and spinal cord, evoked potentials (EP) and cerebrospinal fluid analysis. 

Key words:
clinical picture; multiple sclerosis