Vitamin D analogs in chronic kidney disease

Abstract:

Analogs are compounds that are structurally similar but have different properties. Calcitriol, a natural analogue of vitamin D, was the first synthesized and introduced in dialysis patients for treating renal osteodystrophy. New vitamin D analogs have less calcemic activity. Their main indication in nephrology is mineral-bone disorders in chronic kidney disease. The most commonly used in nephrology are calcitriol, paricalctol, alfacalcidiol and doxercalciferol. Maxacalcitol and phalecalcitriol are only available on the market in Japan. There are used for treatments secondary hyperpathyreoidism in dialysis patients. In addition to the effect on markers of bone metabolism, vitamin D analogues can have a beneficial effect on other organ systems and on the reduction of proteinuria. The choice of vitamin D analogue will depend on availability and clinical indication.

Key words:
calcitrol; mineral-bone disorders in chronic kidney disease; paricalcitol; vitamin D analogues