Effects of vitamin D supplementation on endocrine-metabolic parameters and fertility in woman with polycystic ovary syndrome

Abstract:

Polycystic ovary syndrome (PCOS) is the most common endocrinological disorder, affecting 12-15% of women of reproductive age. It is characterized by menstrual cycle irregularities, anovulatory infertility, hyperandrogenism, and metabolic disorders such as insulin resistance, type 2 diabetes, dyslipidaemia and obesity. Due to the complex and insufficiently elucidated etiopathogenesis, the optimal treatment of this syndrome is still under debate. Studies have shown positive effect of vitamin D replacement therapy on hormonal status, infertility treatment outcomes, variables of glucose homeostasis, lipid concentrations, and biomarkers of inflammation and oxidative stress among women with PCOS and vitamin D deficiency.

Key words:
anovulatory infertility; polycystic ovary syndrome; vitamin D