Novel treatment options for gout

Abstract:

Gout (gouty arthritis) is the most common metabolic rheumatic disease characterized by elevated levels of uric acid in serum (hyperuricemia), recurring attacks of acute arthritis, deposition of uric crystals in joints and other tissues, thus leading to structural and functional damage. Despite the accepted guidelines for treatment there is an increase in the prevalence of gout, probably partly due to inadequate treatment, but also due to the limitations in the application of standard therapy. It is therefore necessary to find new treatment options, acting on different pathogenetic mechanisms of the disease. Based on new insights in today’s clinical practice there are several new medications available for the treatment of hyperuricemia, and for the treatment and prevention of relapses of acute gout attacks, as well as the progression of chronic diseases. 

Key words:
canakinumab; febuxostat; gout; IL-1 blockers; lesinurad; pegloticase; treatment