MEDIX, God. 27 Br. 147/148  •  Pregledni članak  •  Hiperbarična medicina HR ENG

Hiperbarična oksigenoterapija u upalnim reumatskim bolestimaHyperbaric oxygen therapy in inflammatory rheumatic diseases

Kristina Franjić, Sanja Jurić Banai, Sead Žiga, Dragan Vujović, Dejan Andrić, Marko Banić

Hiperbarična oksigenoterapija (HBOT) podrazumijeva primjenu 100%-tnoga kisika na tlakovima većima od jednoga bara. Upalne reumatske bolesti obuhvaćaju velik broj stanja koja zahvaćaju mišićno-koštani sustav, posebice zglobove, ali i tetive, ligamente, mišiće te kosti. Očituju se upalom, bolom i narušenom funkcijom mišićno-koštanoga sustava. Smatra se da HBOT u upalnim reumatskim bolestima može biti koristan zbog indukcije kontroliranog oksidativnoga stresa koji uzrokuje aktivaciju mnogih signalnih puteva koji dovode do potencijalnih kliničkih koristi poput smanjenja upalnog odgovora. Na animalnim modelima otkriveni su i stanični te molekularni mehanizmi kojima HBOT djeluje na inflamatorni i neuropatski bol. Iz područja upalnih reumatskih bolesti, najviše je objavljenih istraživanja na temu liječenja reumatoidnog artritisa HBOT-om. Rezultati sugeriraju da se HBOT može preporučiti reumatskim bolesnicima kao dodatna terapija u svrhu smanjenja simptoma ili čak postizanja remisije.

Ključne riječi:
antinocicepcija; fibromialgija; hiperbarična oksigenoterapija; osteoartritis; reumatoidni artritis; reumatologija

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Hyperbaric oxygen therapy (HBOT) involves the application of 100% oxygen at pressures greater than one bar. Inflammatory rheumatic diseases include a large number of conditions that affect the musculoskeletal system, especially joints, but also tendons, ligaments, muscles and bones. They are manifested by inflammation, pain and impaired function of the musculoskeletal system. It is thought that HBOT in inflammatory rheumatic diseases may be beneficial due to the induction of controlled oxidative stress that causes the activation of many signalling pathways leading to potential clinical benefits such as a reduction in the inflammatory response. Cellular and molecular mechanisms by which HBOT acts on inflammatory and neuropathic pain have been studied in animal models. In the field of inflammatory rheumatic diseases, most research has been published on the treatment of rheumatoid arthritis with HBOT. The results suggest that HBOT may be recommended to these patients as adjunctive therapy for reducing symptoms or even achieving remission.

Key words:
antinociception; fibromyalgia; hyperbaric oxygen therapy; osteoarthritis; rheumatoid arthritis; rheumatology