MEDIX, God. 15 Br. 80/81  •  Autorski pregled  •  Psihijatrija HR ENG

Metabolički sindrom i antipsihoticiMetabolic syndrome and antipsychotic medications

Vera Folnegović Šmalc

Antipsihotici su lijekovi koji se koriste u liječenju shizofrenih i ostalih psihotičnih bolesnika. Spadaju u skupinu lijekova s relativno čestim nuspojavama, koje su često za bolesnika vrlo neugodne i mukotrpne, a ponekad i po život opasne. U tu skupinu nuspojava spadaju i metabolički sindrom, dijabetes tipa II, porast tjelesne težine i kardiovaskularne bolesti. Kako je trajanje liječenja većine shizofrenih bolesnika doživotno, potrebno je posebnu pažnju posvetiti odabiru onog lijeka ili lijekova, koji kod konkretnog bolesnika dovode do najmanjeg broja nuspojava i onih koji su za konkretnog bolesnika najbolje podnošljivi. Kako se porast težine javlja kao nuspojava velikog broja antipsihotika, potrebno je i preventivno provoditi određene vježbe i druge poznate specijalne programe, kako bi se prevenirao razvoj metaboličkog sindroma i time utjecalo na bolju adherentnost i kvalitetu življenja bolesnika

Ključne riječi:
antipsihotici; metabolički sindrom; nuspojave

Članak u cijelosti pročitajte u tiskanom izdanju MEDIX, God. 15 Br. 80/81

Antipsychotic medications are used in the treatment of patients with schizophrenia and other psychotic disorders. They belong to a group of medications that are relatively often associated with adverse effects, which frequently cause discomfort and distress to patients and may even be fatal. Among these adverse effects are metabolic syndrome, type 2 diabetes mellitus, increase in body weight and cardiovascular diseases. Since the treatment of patients with psychotic disorders is life-long, it is important to carefully choose the medications that will be best tolerated by the patient and associated with as few as possible adverse effects. Given that increase in body weight is a side effect of many antipsychotic agents, preventive exercise and other special programs are required to prevent the development of metabolic syndrome and improve the compliance and quality of life of these patients.

Key words:
adverse effects; antipsychotic agents; metabolic syndrome X