MEDIX, God. 16 Br. 86  •  Autorski pregled  •  Oftalmologija HR ENG

LIPCOF i lubrikacija okaLIPCOF and eye lubrication

Igor Petriček, Tvrtka Benašić, Mario Bradvica, Dorotea Ivančić, Goranka Petriček, Marija Štefanović

LIPCOF (Lid parallel conjunctival folds - nabori spojnice paralelni s rubom vjeđe) dijagnostička je metoda disfunkcije suznoga filma prvi put opisana 1995. godine od grupe autora na čelu s prof. Hoehom. No, iako nalaz nabora visoko korelira sa simptomima disfunkcije suznog filma, nije poznat uzrok njihova nastanka. Istraživanje provedeno tijekom ljeta i jeseni 2009. godine od strane 16 oftalmologa iz raznih krajeva Hrvatske ispitalo je učinak lokalno apliciranih kapi za oči s podmazujućim učinkom na simptome i znake „suhoga oka“, s posebnim osvrtom na nabore spojnice. U istraživanje je bilo uključeno 229 ispitanika. Nakon 14 dana liječenja kapima za oči s podmazujućim učinkom (hidroksipropil guar), uočena je statistički značajna redukcija vrijednosti LIPCOF-a, simptoma i znakova disfunkcije suznoga filma. Rezultati istraživanja ukazuju na utjecaj pojačanog trenja površine oka pri treptanju na simptome i znakove „suhoga oka“, njegov utjecaj na nastanak nabora spojnice te njihovu reverzibilnost po primjeni podmazujuće terapije 

Ključne riječi:
bolesti spojnice; hidroksipropil guar; otopine za oko; sindrom suhog oka; suze

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LIPCOF (Lid parallel conjunctival folds) is a diagnostic tool, which was first described in 1995 by Hoeh and colleagues. Although the presence of folds highly correlates with tear dysfunction symptoms, their aetiology is still unknown. Our study, performed in the summer and fall of 2009 by 16 ophthalmologists across Croatia, investigated the effect of topical therapy with lubricating eye drops on the signs and symptoms of “dry eye” and, especially, on conjunctival folds (LIPCOF). There were 229 patients enrolled in the study. After 14 days of therapy with lubricating eye drops (hydroxypropyl guar), a statistically significant reduction in LIPCOF score and symptoms and signs of tear film dysfunction was observed. The results of this study indicate that the increased ocular surface friction during blinking influences the symptoms and signs of “dry eye”, which contributes to the development of conjunctival folds. The study also showed the reversibility of “dry eye” signs and symptoms after lubricating therapy. 

Key words:
conjunctival diseases; dry eye syndromes; hydroxypropyl guar; ophthalmic solutions; tears