MEDIX, God. 14 Br. 78  •  Pregledni članak  •  Gastroenterologija HR ENG

Celijakija – česta bolest u odrasloj dobiCeliac disease – a common disorder in adults

Silvija Čuković-Čavka

Celijakija ili glutenska enteropatija česta je kronična bolest (prevalencija 1%) koju karakterizira poremećeni imunološki odgovor T-limfocita na gluten u bolesnika s genetskom predispozicijom. Bolest ima vrlo šarenu kliničku sliku, a mogu nastupiti ozbiljne komplikacije ako se ne liječi. S obzirom na atipične manifestacije bolesti, u odrasloj dobi bolest se često ne dijagnosticira pravovremeno. Kao zlatni standard u postavljanju dijagnoze ostaje biopsija tankog crijeva iako su novi serološki testovi vrlo specifični (antiendomizijsko antitijelo, antitijelo na tkivnu transglutamnazu). Bolest se liječi doživotnom bezglutenskom dijetom. Edukacija bolesnika je ključna za uspješno liječenje. Bolesnici koji se ne pridržavaju bezglutenske dijete imaju češće rizike za zdravlje od onih koji su na dijeti

Ključne riječi:
celijakija; dijeta; edukacija bolesnika; gluten; serološko testiranje

Članak u cijelosti pročitajte u tiskanom izdanju MEDIX, God. 14 Br. 78

Celiac disease or gluten-sensitive enteropathy is a common (1% prevalence) chronic disorder characterised by an abnormal T-cell response to gluten in genetically predisposed individuals. The disease has various clinical manifestations and serious complications can occur if it is left untreated. In case of atypical manifestations, the diagnosis of adult celiac disease is often delayed. Endoscopic small bowel biopsy remains the gold standard in the diagnosis of celiac disease, although there are new, very specific serological tests available today (anti-endomysial antibody, anti-tissue transglutaminase antibody). Management of celiac disease includes a lifetime commitment to a gluten-free diet and necessary dietary supplementation. Patient education is crucial to successful treatment. Patients not adhering to gluten-free diet have greater health risks than patients who adhere to this treatment.

Key words:
celiac disease; diet therapy; gluten; serologic tests; patient education as topic